Effervescent Tablet for Dysphagia Treatment

It is a medical term used in the health field to describe swallowing problems that occur while eating or drinking. In people suffering from this condition, the food they eat comes back from the stomach to the mouth through a tube-like mechanism.

Dysphagia can be of 2 types:

• Oropharyngeal (Problem towards the esophagus)
• Esophageal (Emptying problem from the oropharynx to the esophagus)

This condition, which applies to people of almost all ages, is generally common in elderly people and children.

What Are the Causes of Dysphagia?

Due to injuries occurring in the brain, nervous system problems, esophageal spasms, and inflammation in the esophagus, the muscles and nerves that help food move toward the stomach cannot function properly. As a result, dysphagia occurs.

At the same time, a low amount of saliva in the mouth cannot provide the necessary lubrication for the food to descend into the stomach.

A Suitable Method for Dysphagia Treatment

Liquid solutions or solid effervescent tablets that can be converted into liquid form are very suitable for the treatment of such conditions.

Effervescent; It is the process of removing carbon dioxide gas from the liquid before it passes into the food.

Effervescent tablets must be dissolved in water before use. In this stage, it dissolves by releasing its carbon dioxide into the water and breaks down. Tablets produced using the effervescent method ensure that the active ingredients in the tablet penetrate and are absorbed into the cells quickly.

The conditions treated with effervescent tablets are as follows;

• H1 Antagonists
• Allergenic Disorders
• Common Cold
• Dizziness
• Cough
• Motion Sickness
• Parenteral H1 Antagonists
• Acute Muscle Dystonia

The active ingredient used in the treatment of such conditions is Chlorpheniramine maleate. This compound is a first-generation alkylamine histamine. The most important feature of CPM is that it blocks acetylcholine and some naturally secreted histamines as a result of allergic reactions.

To prevent such health problems (Dysphagia and low saliva amount), effervescent tablets of Chlorpheniramine maleate (CPM) are used.

What Are the Substances Used in Dysphagia Treatment?

Controlling atmospheric moisture is very important for dysphagia treatment. For this, acid additives that will provide optimum efficiency must be used.

Acids with less hygroscopic properties should be used so that effervescent tablets are less affected by atmospheric moisture and release sodium carbonate and sodium bicarbonate gas better. For this purpose, Tartaric Acid and Fumaric Acid are less hygroscopic in effervescent tablets compared to Citric Acid. The higher the hygroscopic value, the more moisture occurs within the tablet and the higher the sticking in the tablet machine.

At the same time, it is also important for the treatment to have a fast effect level.

What Are the Substances Used?

• Chlorpheniramine maleate (CPM)
• Tartaric Acid
• Fumaric Acid
• Sodium Bicarbonate
• Sodium Benzoate
• Lactose
• Sucrose
• Polyvinylpyrrolidone (PVP)

Effervescent tablets produced with the combination of these substances show a faster disintegration property and a faster drug distribution effect regarding CPM. The amounts of substances in this combination are the most important factor for obtaining optimum efficiency.

Use of Polyvinylpyrrolidone in Dysphagia Treatment:

Polyvinylpyrrolidone is a polymer widely used in many industrial and medical applications. It can be used as a binder, solvent, or stabilizer in the production of orally disintegrating tablets, pills, and similar pharmaceutical formulations.