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During compression processes, the substances to be added to the tablet are prepared by mixing the active ingredients and excipients in powder form with each other. Tablets produced after such direct compression processes become resistant to heat and moisture.
The desired properties of the excipients within the tablet are as follows.
- Flowability
- Compressibility
- Low moisture sensitivity
- Rapid Disintegration Effect
A porous structure is imparted to the tablets with Microcrystalline Cellulose.
Among the most important benefits in direct tablet compression processes is that it provides excellent mechanical strength with very good bonding.
Due to certain limitations in the use of Microcrystalline Cellulose, the properties of this chemical compound must be enhanced by modifying it with another chemical.
Microcrystalline Cellulose‘s Properties: What Should Be Done to Improve Them?
Another excipient required to improve other properties needed for direct compression is Chitosan (CTS). With the use of this substance, water solubility and bioavailability properties can be increased. Therefore, Chitosan (CTS) can be directly incorporated.
At the same time, it provides powder flowability and a rapid disintegration effect. In such direct compression processes, Chitosan (CTS) and Microcrystalline Cellulose have different properties.
It can exhibit improvable properties in the production of drugs with poor compressibility characteristics.
Binders are used to hold the active ingredients within the tablets together and to increase the durability of the tablets. For example, substances such as cellulose derivatives (HPMC, HPC, CMC), starch, polyethylene glycol (PEG), and methyl cellulose (MC) can be used. Fillers are used to increase the volume of tablets and ensure dosage uniformity. Among the most commonly used fillers are lactose, microcrystalline cellulose (MCC), dibasic calcium phosphate (DCP), and mannitol bulunur.
